Discovering the Sweet
Mysteries ofChocolate
By Ellen Kuwana
Neuroscience for Kids Staff Writer

Chocolate History

More than 3000 years ago, the Mayans and Aztecs of the Americasconsumedchocolate. These people drank cacao, or the chocolate bean, which wasground into hot water, like the hot chocolate we drink today. However,their cacao was rather bitter and had chilies in it. For those of us whohoard our chocolate candies, it is easy to understand why the Mayans andAztecs used cacao beans as currency. Imagine using M&Ms instead of coins!

How did chocolate spread around the world? In 1502, on his fourth and lastvoyage to the New World, Christopher Columbus came upon a canoe that wastransporting agricultural products, including cacao beans. He seized thecontents of the canoe and brought cacao back to Spain. Chocolate did notbecome popular for many years in Europe, but decades later, the Spaniardsadded sugar to the cacao, and the rest, as they say, is history. Chocolatesoon became the preferred drink of the royal courts in Europe. The beliefwas that chocolate could cure any illness.

Haveyou ever seen a cacao bean, (or, as it is more commonly known, acocoa bean)? These beans grow on a tree called Cacao theobroma.The cacao tree is pollinated by insects called midges and by bats and isgrown only within 10-20 degrees latitude of the Equator. Theseregions include West Africa, Central America, parts of South America, andthe Caribbean Islands. The beans, which grow in the fruit pods of thetree, are generally harvested twice a year. Each pod is about the size ofa hand and contains 20-50 beans. The pods turn bright yellow, orange, orred when ripe. The beans are dried, and then the center part is removed byhand and allowed to ferment. After the beans dry again, they are sold.The chocolate manufacturer must separate the beans from any debris, removethe hard outer shell, and grind the center part of the bean.

Chocolate, Chocolate Everywhere

Chocolate candy bars, after-dinner mints, brownies, truffles, doughnuts,chocolate milk-if it has chocolate in it, we eat it. Hot, cold, solid,liquid, over ice cream...even over meat?! Yes, a Mexican sauce called"mole" uses unsweetened chocolate in a sauce that is served over meat. It's a versatile flavor, chocolate. Chocolate has been blamed for acneand tooth decay, but research has found that it is innocent of theseevils. That must have made lots of people worldwide sigh in relief: thechocolate industry sells five billion dollars worth of chocolate each yearin the U.S. alone. The U.S. is only the eighth largest consumer ofchocolate. Switzerland, whose citizens eat more than 21 pounds per personeach year, leads the world in chocolate consumption.

An Appetite for Chocolate

Why do we crave chocolate? There aretimes when nothing else tastes as good as chocolate. There are times whenyou want nothing else. Nothing else will do. There's evena name for someone who craves chocolate: a chocoholic. It's almost anuncontrollable urge.

Some scientists wondered why the average personin the U.S. eats 11 pounds of chocolate each year. They decided to analyzethe contents of chocolate to find out how those compounds might affect ourbrains, and thus our moods. Just as caffeine seems toperk people up, chocolate seems to make us feel happy.

Chocolate contains approximately 380 known chemicals, so it's nowonder it's difficult to figure out why chocolate is such a favoritetreat. And who's to say that it's only one or two things in chocolate thatcause us to feel happy? Many of the chemicals in chocolate are found inother foods, yet we don't buy heart-shaped bananas to show that specialsomeone that we care for them. It may be a unique chemical combinationthat gives chocolate its edge over vanilla, berry, and caramel. Although chocolate has been said to improve mood, it containssaturatedfat and sugar, too, so don't overindulge-it's not the healthiest food. Andkeep chocolate away from Spot! A two-ounce piece of chocolate can be fatalto a dog because it can not digest one compound in chocolate calledtheobromine. Chocolate can also make some small children sick for the samereason.

Chocolate and the Nervous System

AdamDrewnowski at the University of Michigan researchedwhether chocolate triggers the production of opioids. Opioids arechemicals, such as those found in opium, that produce a feeling ofwell-being (euphoria). Drewnowski found that eating chocolate causes thebrain to produce natural opiates, which dulI pain and increase a feelingof well-being. If the receptors in the brain that signal the presence ofopioids were blocked, chocolate bingeing decreased. It was not shown,however, if this was caused by the high fat or sugar content of chocolatecandy.

Researchers at the Neurosciences Institute in San Diego, EmmanuellediTomaso (she's now at Harvard University) and Daniele Piomelli (he's nowat the University of California, Irvine) looked into the chemicalcomponents of chocolate. They found three substances inchocolate that "could act as cannabinoid mimics either directly (byactivating cannabinoid receptors) or indirectly (by increasing anandamidelevels)." What do all these big words mean? A little backgroundinformation may help make this more understandable.

A receptor is a structure on the surface of a cell that interacts withcertain chemicals. Receptors have different shapes, and thus interact withspecific molecules. diTomaso describes this interaction like this: "theactivecompound will lock itself to the protein and that triggers a reactioninside the cell." Cannabinoids are substances that act likecannabis, also known as marijuana. The activechemical in marijuana is called tetrahydrocannabinol (THC), and there arereceptors in the brain that bind THC. When THC binds to these receptors,the person feels "high." Anandamide is a lipid that is normally found inthe brain; it can bind to the same receptors as THC and thus produce asimilar effect to "being high."

Does chocolate affect the brain in the same way marijuana does? There arechemicals in chocolate that act like THC, resulting inproduction of dopamine, a neurotransmitter. However, there is no THC inchocolate, so you aren't breaking the law by eating chocolate. One of thecompounds in chocolate is anandamide, which is already producedin your brain. If anandamide is already in your brain, then why don't youfeel happy all the time? Well, anandamide is broken down quickly, so itisn't around long in your brain to make you smile. But chocolate mayextend the feelings of well being. Piomelli's research indicates thatthereare two chemicals in chocolate which inhibit the natural breakdown ofanandamide. This may be a reason why we like to eat chocolate! And darkchocolate contains more of these compounds than milk chocolate.

Eating a bar of chocolate will not make you feel giddy or "high." This maybe because anandamide and the two compounds that enhance its effect areshort-lived and localized in the brain. THC activates many receptorsthroughout the brain, so it has a much larger effect.Chocolate's effect is limited because anandamide is not present all overthe brain. Scientists doubt if anandamide and other chemicals inchocolate have much effect because they are present only in small amounts.Christian Felder at the National Institute of Mental Health estimates thata 130-pound person would have to eat 25 pounds of chocolate at one time toget any marijuana-like effect. Also, since these compounds areeaten, it's difficult to determine how much enters the bloodstream andactually reaches the brain.

There may also be other explanations for the feelings caused by chocolateand these may have nothing to do with cannabinoids, anandamide, orreceptors. There are many other components in chocolate that may play arole in its popularity. Eating chocolate may be pleasurable because of aunique interaction among a few of its components.

Chocolate also contains phenylethylamine, a chemical related toamphetamines. Like amphetamines, this chemical causes blood pressure andblood-sugar levels to rise, resulting in a feeling of alertness andcontentment. Phenylethylamine has been called the "love-drug" because itquickens your pulse, as if you are in love. Caffeine in chocolate mayalso cause feelings of alertness and a pounding heart. Other stimulants inchocolate include theobromine and methylxanthines. Thesecaffeine-relatives are weaker than caffeine-you'd have to eat more than 12Hershey bars to get as much caffeine as there is in one cup of coffee. Allof these stimulants increase the activity of neurotransmitters in thebrain.


TheSynapse
An electrical impulse willtrigger therelease of neurotransmitters from vesicles (red dots in the picture)in the presynaptic terminal. Molecules of neurotransmitter crossthe synaptic cleft and bind to receptors on thepostsynaptic membrane.

Whatever the true reason for chocolate's popularity, scientists willcontinue to investigate the sweet mysteries of cacao. In the meantime,grab a bar for yourself and a box for your Valentine.

Life is sweeter withchocolate.

Forreferences and more information on chocolate, see:

  1. Brain Cannabinoids inChocolate, Nature, August 22, 1996, pp. 677-678 by diTomaso, E.,Beltramo, M., and Piomelli, D.
  2. Chocolate-An Introduction
  3. Chocolate-Melting the Myths - An in-depth look at the chemical components of chocolate.
  4. Chocolate May Mimic Marijuana - October 1996
  5. Chocolate: the Legal 'High', August 21, 1996, MedicalTribune News Service by Mann, D.
  6. Chocolate's effect on brain likened to marijuana's - August21, 1996
  7. Historyand Science of Chocolate
  8. Marijuana and Chocolate, AIDS Treatment News 257-October 18, 1996 by James, J.S.
  9. Prescription-Strength Chocolate: Food for Thought - October 12,1996 - A report on the chemistry behind chocolate and the brain.
  10. The Sweet Lure of Chocolate - All about the history of chocolate and research about its effects, plus alist of references and related links.
  11. Second Endogenous Substance Similar to THC Found - September/October1997
  12. Study Disputes Chocolate "High" - December 17, 1998
  13. Sweet Science: Chocolate may really be a 'love drug' for the brain - February 10, 1997
  14. Sweet Seduction - History of chocolate - I
  15. History of Chocolate- II
  16. The Science of Love - Research into why we love chocolate.
  17. Trick or Treat from Food Endocannabinoids?, Nature, Vol. 396,December 17, 1998, pp. 636-637, by DiMarzo, Sepe,DePetrocellis, Berger, Crozier, Fride and Mechoulam - A letter to Nature raising questions and concerns about the originalreport ofendocannabinoids in chocolate, plus a reply by two of the authors of thereport, Beltramo and Piomelli.

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